Jun 24, 2022
Causality and Autoencoders in the Light of Drug Repurposing for COVID-19
Date: June 24, 2022 |
1:00 pm –
2:00 pm
Speaker:
Caroline Uhler, Massachusetts Institute of Technology
Location: Heinzel Seminar Room / Office Bldg West (I21.EG.101)
Language:
English
Massive data collection holds the promise of a better understanding of complex phenomena and ultimately, of better decisions. An exciting opportunity in this regard stems from the growing availability of perturbation / intervention data (for example in genomics, advertisement, education, etc.). In order to obtain mechanistic insights from such data, a major challenge is the development of a framework that integrates observational and interventional data and allows causal transportability, i.e., predicting the effect of yet unseen interventions or transporting the effect of interventions observed in one context to another. I will propose an autoencoder framework for this problem. In particular, I will characterize the implicit bias of overparameterized autoencoders and show how this links to causal transportability and can be applied for drug repurposing in the current COVID-19 crisis.
