Skip to main content

Sixt Group

Cellular Morphodynamics

Immune cells zip through our bodies at high speeds to fight off infections and diseases. The Sixt group works at the interface of cell biology and immunology to investigate how cells are able to migrate through tissues.

Most cells in our bodies are stationary, forming solid tissues and encapsulated organs. One exception are leukocytes, immune cells essential for both the innate and adaptive immune responses to infections. Leukocytes migrate with extraordinary speed and are used by the Sixt group as a model to study cell migration. The group works at the interface of cell biology, immunology, and biophysics, and aims to identify basic mechanistic principles that are equally important for developmental processes and cancer cells. One research focus is how the cell’s internal skeleton generates and transduces the force to change shape, move the cell body and interact with other cells. The group also investigates how cells navigate along guidance cues, specifically how they orient their polarity axis in response to chemotactic gradients. In their work, the members of the Sixt group combine genetics, pharmacology, micro-engineering, surface chemistry, and advanced imaging approaches, as well as in vivo imaging techniques.




Team

Image of Zane Alsberga

Zane Alsberga

PhD Student

Image of Mario Avellaneda

Mario Avellaneda

Postdoc

Image of Nikola Canigova

Nikola Canigova

PhD Student


Image of Malgorzata Cichon

Malgorzata Cichon

Postdoc

Image of Ingrid de Vries

Ingrid de Vries

Research Technician

+43 2243 9000 3804

Image of Francesco Di Matteo

Francesco Di Matteo

Postdoc


Image of Manjunath Javoor

Manjunath Javoor

PhD Student

Image of Reena Kumari

Reena Kumari

Postdoc

Image of Sergio Lembo

Sergio Lembo

Postdoc


Image of Ziqiang LI

Ziqiang LI

Postdoc

Image of Isabelle Mayer

Isabelle Mayer

PhD Student

Image of Theresa Muthspiel

Theresa Muthspiel

PhD Student


Image of Patricia Rodrigues

Patricia Rodrigues

PhD Student


Current Projects

Environmental control of leukocyte migration | Cellular force generation and transduction | Interpretation of chemo-attractive gradients


Publications

Pimenta-Marques A, Perestrelo T, Dos Reis Rodrigues P, Duarte P, Ferreira-Silva A, Lince-Faria M, Bettencourt-Dias M. 2024. Ana1/CEP295 is an essential player in the centrosome maintenance program regulated by Polo kinase and the PCM. EMBO reports. 25(1), 102–127. View

Caballero Mancebo S, Shinde R, Bolger-Munro M, Peruzzo M, Szep G, Steccari I, Labrousse Arias D, Zheden V, Merrin J, Callan-Jones A, Voituriez R, Heisenberg C-PJ. 2024. Friction forces determine cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization. Nature Physics. View

Stopp JA. 2023. Neutrophils on the hunt: Migratory strategies employed by neutrophils to fulfill their effector function. Institute of Science and Technology Austria. View

Riedl M. 2023. Synchronization in collectively moving active matter. Institute of Science and Technology Austria. View

Wruck F, Avellaneda Sarrió M, Naqvi MM, Koers EJ, Till K, Gross L, Moayed F, Roland A, Heling LWHJ, Mashaghi A, Tans SJ. 2023.Probing Single Chaperone Substrates. In: Biophysics of Molecular Chaperones. New Developments in NMR, vol. 29, 278–318. View

View All Publications

ReX-Link: Michael Sixt


Career

Since 2013 Professor, Institute of Science and Technology Austria (ISTA)
2010 – 2013 Assistant Professor, Institute of Science and Technology Austria (ISTA)
2008 – 2010 Endowed Professor, Peter Hans Hofschneider Foundation for Experimental Biomedicine
2005 – 2010 Group Leader, Max Planck Institute of Biochemistry, Martinsried, Germany
2003 – 2005 Postdoc, Institute for Experimental Pathology, Lund, Sweden
2003 MD, University of Erlangen, Germany
2002 Approbation in human Medicine


Selected Distinctions

2022 ERC Synergy Grant
2016 ERC Consolidator Grant
2014 EMBO Member
2013 European Biophysical Societies Association (EBSA) Young Investigator Medal
2013 Elected member of the Young Academy of the Austrian Academy of Sciences (ÖAW)
2012 Ignaz L. Lieben Award
2011 ERC Starting Grant
2011 FWF START Award
2008 Endowed Professor of the Peter Hans Hofschneider Foundation
2003 Novartis dissertation prize


Additional Information

Download CV
View Sixt group website



theme sidebar-arrow-up
Back to Top